Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders
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چکیده
منابع مشابه
18F-FDOPA PET and PET/CT accurately localize pheochromocytomas.
UNLABELLED Successful treatment of pheochromocytoma requires accurate diagnosis and localization of tumors. Herein, we investigated the accuracy of PET using 3,4-dihydroxy-6-(18)F-fluoro-phenylalanine ((18)F-FDOPA), an amino acid transporter substrate, as an independent marker for detection of benign and malignant pheochromocytomas. METHODS The study comprised 25 consecutive patients (9 men, ...
متن کامل18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy.
UNLABELLED We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG. METHODS Eighty-one patients undergoing evaluation for brain tumors were studied. Initially, 30 patients underwent PET with (18)F-FDOPA and (18)F-FDG within the same week. Tracer kinetics in normal brain and tumor tissues were...
متن کاملEvaluation of D-isomer of 18F-FBPA for oncology PET focusing on the differentiation of glioma and inflammation
Objective(s): L-4-borono-2-18F-fluoro-phenylalanine (L-[18F]FBPA), a substrate of L-type amino acid transporter 1 (LAT1), is a tumor-specific probe used in positron emission tomography (PET). On the other hand, it has not been examined whether another isomer D-[18F]FBPA accumulates specifically in the tumor. He...
متن کاملJoint Factor and Kinetic Analysis of Dynamic FDOPA PET Scans of Brain Cancer Patients
Kinetic analysis is an essential tool of Positron Emission Tomography image analysis. However it requires a pure tissue time activity curve (TAC) in order to calculate the system parameters. Pure tissue TACs are particularly difficult to obtain in the brain as the low resolution of PET means almost all voxels are a mixture of tissues. Factor analysis explicitly accounts for mixing but is an und...
متن کاملThe impact of dopamine on aggression: an [18F]-FDOPA PET Study in healthy males.
Cerebral dopamine (DA) transmission is thought to be an important modulator for the development and occurrence of aggressive behavior. However, the link between aggression and DA transmission in humans has not been investigated using molecular imaging and standardized behavioral tasks. We investigated aggression as a function of DA transmission in a group of (N = 21) healthy male volunteers und...
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ژورنال
عنوان ژورنال: NeuroImage: Clinical
سال: 2020
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2019.102161